![](https://static.wixstatic.com/media/88f6e2_9e9f05a593c3414ead2f0bd07ba1f24c~mv2.png/v1/fill/w_400,h_318,al_c,q_85,enc_auto/88f6e2_9e9f05a593c3414ead2f0bd07ba1f24c~mv2.png)
\documentclass{article}
\usepackage{tikz}
\usetikzlibrary{shapes,shadows,arrows}
\usetikzlibrary{backgrounds}
\begin{document}
%line thickness styles: ultra thin, very thin, (thin), semithick, thick, very thick, ultra thick
%line dash styles: loosely dashed, densely dashed, loosely dotted, densely dotted
\tikzstyle{decision}=[diamond,draw,fill=gray!50]
%\tikzstyle{arrow}=[draw,-latex’,very thick]
\tikzstyle{arrow}=[draw,-latex’]
\tikzstyle{line}=[draw]
\tikzstyle{cloud}=[draw=gray!0,very thick,block,rounded corners,fill=gray!2, minimum width=15mm, minimum height=15mm,node distance=5em]
\tikzstyle{vagueblock}=[draw=gray!30,rectangle,rounded corners,fill=gray!30,text centered, minimum width=15mm, minimum height=15mm,node distance=5em]
\tikzstyle{block}=[draw,rectangle,rounded corners,fill=gray!30,text centered, minimum width=15mm, minimum height=15mm,node distance=5em]
\tikzstyle{empblock}=[draw,rectangle,rounded corners,minimum width=8cm,minimum height=5cm]
\tikzstyle{grayblock}=[draw,fill=gray!30,rectangle,rounded corners,minimum width=7.5cm,minimum height=4.5cm]
\begin{tikzpicture}
%shapes
\node[vagueblock](AAA){\parbox{7cm}{\centering Abdominal aorta aneurysm patients \\Patients=355}};
\node[block,below of=AAA,xshift=2cm,yshift=-1cm](AAAfu){\parbox{3cm}{\centering Follow-up patients \\ Patients=149}};
\node[block,below of=AAA,xshift=-2cm,yshift=-1cm](AAAop){\parbox{3cm}{\centering Post-op patients\\ Patients=206}};
%\node[empblock,below of=AAA,yshift=-0.4cm](emp){};
\begin{scope}[on background layer]
\node[grayblock,below of=AAA,yshift=-0.4cm](emp){};
\end{scope}
\node[block,left of=AAA,xshift=-5cm](Controls){\parbox{4cm}{\centering Healthy controls \\Patients=196}};
\node[cloud,below of=Controls,yshift=-1cm](TCC){\parbox{4cm}{\centering Nested case-control\\ Endpoint: TCC}};
\node[cloud,above of=Controls,yshift=1cm](C4BP){\parbox{4cm}{\centering Nested case-control\\ Endpoint: C4BP}};
\node[cloud,above of=AAA,yshift=1cm](size){\parbox{7cm}{\centering Retroperspective\\ Endpoint: Aneurysm size}};
\node[cloud,below of=AAA,yshift=-4cm](followup){\parbox{7cm}{\centering Follow-up study \\ Endpoints: Survival, aneurysm size, C4BP}};
\path[arrow](size) — (emp);
\path[arrow](TCC)–(AAAop);
\path[arrow](TCC)–(Controls);
\path[arrow](C4BP)–(emp);
\path[arrow](C4BP)–(Controls);
\path[arrow](followup)–(AAAfu);
\end{tikzpicture}
\end{document}
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